Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 4/20 | 0.33 |
| ▸ | ACE | P12821 | 3/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | GGT1 | P19440 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26766 | 0.97 | — | — | |
| SCHEMBL181160 | 0.97 | TSHR (0.55) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| Rubidium SCHEMBL30482330 | 0.94 | TSHR (0.52) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL337233 | 0.94 | TSHR (0.52) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| Potassium SCHEMBL29362014 | 0.94 | TSHR (0.52) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| Lithium SCHEMBL30482376 | 0.94 | TSHR (0.52) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL10455659 | 0.94 | TSHR (0.52) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL6557046 | 0.94 | TSHR (0.52) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL29462916 | 0.94 | TSHR (0.52) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL28671832 | 0.94 | TSHR (0.52) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1600484-B1 | WHITE CONDUCTIVE PRIMER COATING COMPOSITION AND METHOD OF FORMING MULTILAYERED COATING FILM | KANSAI PAINT CO LTD (JP) | 2007-10-24 | — | — | EP | disclosed |