Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | CTSC | P53634 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500805 | 0.94 | RHOA (0.48) | RHOANPC1RAB9AABL1BCR | |
| SCHEMBL5500283 | 0.89 | CTSC (0.51) | CHEK2AURKACTSCCTSLSYK | |
| SCHEMBL5523916 | 0.88 | KCNK3 (0.52) | NPC1RAB9AABL1BCRPRKCA | |
| SCHEMBL5499256 | 0.88 | RHOA (0.42) | RHOANPC1RAB9AABL1BCR | |
| SCHEMBL5513122 | 0.81 | CTSC (0.52) | ABL1CHEK2HDAC3HDAC1HDAC2 | |
| SCHEMBL5494755 | 0.81 | CTSC (0.64) | NPC1RAB9AABL1AURKACTSC | |
| SCHEMBL27039947 | 0.81 | RHOA (0.52) | RHOANPC1RAB9AABL1BCR | |
| SCHEMBL27040648 | 0.80 | RHOA (0.60) | RHOANPC1RAB9AABL1BCR | |
| SCHEMBL5504570 | 0.80 | RHOA (0.53) | RHOANPC1RAB9AABL1BCR | |
| SCHEMBL29836837 | 0.80 | RHOA (0.50) | RHOANPC1RAB9AABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | claimed |
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | claimed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293484-A1 | Thiophene Heteroaryl Amines | SUGEN, INC. | 2007-12-20 | — | — | US | disclosed |
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293484-A1 | Thiophene Heteroaryl Amines | TTK, CHEK2, ABL1 | RHOA 1263/4885NPC1 2133/4885RAB9A 937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.