Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | UGCG | Q16739 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.42 |
| ▸ | PDE4A | P27815 | 6/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1143639 | 0.94 | PDE4A (0.42) | NR1I2UGCGPDE4BPDE4CPDE4A | |
| SCHEMBL1143520 | 0.93 | PDE4B (0.49) | NR1I2UGCGPDE4BPDE4CPDE4A | |
| SCHEMBL1143947 | 0.93 | PDE4A (0.46) | NR1I2UGCGPDE4BPDE4CPDE4A | |
| SCHEMBL1143603 | 0.92 | TP53 (0.41) | NR1I2UGCGPDE4BPDE4CPDE4A | |
| SCHEMBL1143737 | 0.92 | TP53 (0.44) | NR1I2UGCGPDE4BPDE4CPDE4A | |
| SCHEMBL1143726 | 0.92 | PDE4B (0.49) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL13002994 | 0.91 | PDE4B (0.51) | NR1I2UGCGPDE4BPDE4CPDE4A | |
| SCHEMBL5511996 | 0.91 | PDE4B (0.51) | NR1I2UGCGPDE4BPDE4CPDE4A | |
| SCHEMBL1143748 | 0.87 | MAPT (0.37) | NR1I2UGCGPDE4BPDE4CPDE4A | |
| SCHEMBL1144302 | 0.87 | PDE4A (0.41) | PDE4BPDE4CPDE4APDE4DTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496878-A4 | METHODS FOR IDENTIFICATION OF MODULATORS OF ANGIOGENESIS, COMPOUNDS DISCOVERED THEREBY, AND METHODS OF TREATMENT USING THE COMPOUNDS | CELGENE CORP (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1496878-A1 | METHODS FOR IDENTIFICATION OF MODULATORS OF ANGIOGENESIS, COMPOUNDS DISCOVERED THEREBY, AND METHODS OF TREATMENT USING THE COMPOUNDS | CELGENE CORPORATION (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003086373-A1 | METHODS FOR IDENTIFICATION OF MODULATORS OF ANGIOGENESIS, COMPOUNDS DISCOVERED THEREBY, AND METHODS OF TREATMENT USING THE COMPOUNDS | CELGENE CORPORATION (US) | 2003-10-23 | — | — | WO | disclosed |