Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.76 |
| ▸ | EDNRA | P25101 | 9/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | TSPO | P30536 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500351 | 0.94 | EDNRA (0.86) | EDNRBEDNRASLC6A2TSPODRD3 | |
| SCHEMBL5501326 | 0.93 | EDNRB (0.89) | EDNRBEDNRASLC6A2TSPODRD3 | |
| SCHEMBL5501162 | 0.91 | EDNRA (0.80) | EDNRBEDNRASLC6A2TSPODRD3 | |
| SCHEMBL5097931 | 0.91 | EDNRB (0.72) | EDNRBEDNRASLC6A2TSPODRD3 | |
| SCHEMBL14289221 | 0.89 | EDNRB (0.65) | EDNRBEDNRA | |
| SCHEMBL14289220 | 0.88 | EDNRB (0.68) | EDNRBEDNRA | |
| SCHEMBL5632235 | 0.88 | EDNRB (0.74) | EDNRBEDNRASLC6A2TSPODRD3 | |
| SCHEMBL19569156 | 0.87 | EDNRA (0.89) | EDNRBEDNRASLC6A2TSPODRD3 | |
| SCHEMBL8802029 | 0.87 | EDNRB (0.84) | EDNRBEDNRA | |
| SCHEMBL4068362 | 0.87 | EDNRB (0.75) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465875-B1 | NOVEL ALKANSULFONAMIDES AS ENDOTHELIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-12-19 | — | — | EP | claimed |
| US-7323465-B2 | Alkansulfonamides as endothelin antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-01-29 | — | — | US | disclosed |
| US-7323465-B2 | Alkansulfonamides as endothelin antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-01-29 | — | — | US | disclosed |