Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412139 | 0.77 | MAPK14 (0.48) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL4408102 | 0.76 | MAPK14 (0.43) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL4408115 | 0.76 | MAPK14 (0.47) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL4409918 | 0.74 | MAPK14 (0.48) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL4408472 | 0.74 | MAPK14 (0.48) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL4417406 | 0.73 | NAMPT (0.45) | MAPK14MAPK10NAMPTCSNK1ECSNK1D | |
| SCHEMBL4410172 | 0.73 | MAPK14 (0.47) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL4406497 | 0.73 | MAPK14 (0.51) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL4410204 | 0.73 | MAPK14 (0.46) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL4408106 | 0.72 | MAPK14 (0.44) | MAPK14MAPK10MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833828-A2 | CONDENSED PYRIDINES AS KINASE INHIBITORS | Palau Pharma, S.A. (ES) | 2007-09-19 | — | — | EP | claimed |
| WO-2006013095-A2 | CONDENSED PYRIDINES AS KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2006-02-09 | — | — | WO | claimed |