Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 17/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158855 | 0.85 | MAPKAPK2 (0.66) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4145652 | 0.84 | MAPKAPK2 (0.74) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4154839 | 0.80 | MAPKAPK2 (0.74) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4154410 | 0.79 | MAPKAPK2 (0.83) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4158612 | 0.78 | MAPKAPK2 (0.75) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4148066 | 0.78 | MAPKAPK2 (0.71) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4149672 | 0.77 | MAPKAPK2 (1.00) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4152101 | 0.77 | MAPKAPK2 (1.00) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4156271 | 0.77 | MAPKAPK2 (0.84) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 | |
| SCHEMBL4147784 | 0.77 | MAPKAPK2 (0.76) | MAPKAPK2ADRA2AADRA2BADRA2CRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781293-A1 | QUINOLINE- AND ISOQUINOLINE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Amphora Discovery Corporation (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2005120509-A1 | QUINOLINE- AND ISOQUINOLINE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |