Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891551 | 1.00 | CYP1A2 (0.44) | CYP1A2CYP2D6CYP2C19LCKFYN | |
| SCHEMBL10806885 | 0.82 | LCK (0.43) | CYP1A2CYP2D6LCKFYNDAO | |
| SCHEMBL2791848 | 0.82 | LCK (0.43) | CYP1A2CYP2D6LCKFYNDAO | |
| SCHEMBL27538928 | 0.80 | CYP2E1 (0.46) | CYP1A2CYP2D6CYP2C19NPC1RAB9A | |
| SCHEMBL29226476 | 0.80 | LCK (0.42) | CYP1A2CYP2D6LCKFYNDAO | |
| Hydrochloric Acid SCHEMBL9402271 | 0.80 | LCK (0.42) | CYP1A2CYP2D6LCKFYNDAO | |
| SCHEMBL253783 | 0.80 | LCK (0.42) | CYP1A2CYP2D6LCKFYNDAO | |
| SCHEMBL27677586 | 0.76 | CYP1A2 (0.57) | CYP1A2CYP2D6LCKFYNDAO | |
| SCHEMBL14625255 | 0.76 | LCK (0.38) | CYP1A2CYP2C19LCKFYNDAO | |
| SCHEMBL72501 | 0.75 | CYP2C9 (0.45) | CYP2D6LCKFYNDAONPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514184-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-1005348-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1998013046-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |
| EP-1399577-B1 | METHOD FOR PRODUCING L-AMINO ACIDS | SHOWA DENKO KK (JP) | 2007-02-07 | — | — | EP | disclosed |
| US-20040248118-A1 | Method for producing l-amino acids | SHOWA DENKO K.K. (JP) | 2004-12-09 | — | — | US | disclosed |
| EP-1399577-A1 | METHOD FOR PRODUCING L-AMINO ACIDS | Showa Denko K.K. (JP) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003000915-A1 | METHOD FOR PRODUCING L-AMINO ACIDS | SHOWA DENKO K.K. (JP) | 2003-01-03 | — | — | WO | disclosed |