Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.59 |
| ▸ | EGFR | P00533 | 7/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.55 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromobenzene SCHEMBL27935204 | 0.88 | EGFR (0.60) | SRCEGFRERBB2GAKMAP2K1 | |
| Ethylbenzene SCHEMBL27459760 | 0.86 | MAP2K1 (0.58) | SRCEGFRERBB2MAP2K1ENPP1 | |
| SCHEMBL27459377 | 0.85 | EGFR (0.62) | SRCEGFRERBB2MAP2K1ABL1 | |
| SCHEMBL4743752 | 0.83 | SRC (0.62) | SRCEGFRERBB2GAKMAP2K1 | |
| SCHEMBL27458918 | 0.82 | SRC (0.50) | SRCEGFRERBB2MAP2K1 | |
| SCHEMBL15279141 | 0.81 | EGFR (0.62) | SRCEGFRERBB2GAKMAP2K1 | |
| SCHEMBL15263585 | 0.81 | SRC (0.59) | SRCEGFRERBB2GAKMAP2K1 | |
| SCHEMBL30080014 | 0.81 | SRC (0.59) | SRCEGFRERBB2GAKMAP2K1 | |
| SCHEMBL1893090 | 0.81 | SRC (0.62) | SRCEGFRERBB2GAKABL1 | |
| SCHEMBL29590073 | 0.81 | SRC (0.62) | SRCEGFRERBB2GAKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | disclosed |
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |
| EP-1218353-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca UK Limited (GB) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001004102-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |