Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2704265 | 1.00 | PIK3CA (0.39) | PIK3CADDB1CRBNAURKBPLK4 | |
| SCHEMBL2704270 | 1.00 | PIK3CA (0.39) | PIK3CADDB1CRBNAURKBPLK4 | |
| SCHEMBL551597 | 1.00 | PIK3CA (0.39) | PIK3CADDB1CRBNAURKBPLK4 | |
| SCHEMBL551598 | 1.00 | PIK3CA (0.39) | PIK3CADDB1CRBNAURKBPLK4 | |
| SCHEMBL549892 | 1.00 | PIK3CA (0.39) | PIK3CADDB1CRBNAURKBPLK4 | |
| SCHEMBL551857 | 0.91 | PIK3CA (0.41) | PIK3CADDB1CRBNHSD11B1 | |
| SCHEMBL550785 | 0.91 | PIK3CA (0.41) | PIK3CADDB1CRBNHSD11B1 | |
| SCHEMBL2700496 | 0.91 | PIK3CA (0.41) | PIK3CADDB1CRBNHSD11B1 | |
| SCHEMBL2699650 | 0.90 | CYP1A2 (0.39) | PIK3CAHCRTR1HCRTR2HSD11B1CYP1A2 | |
| SCHEMBL551157 | 0.90 | CYP1A2 (0.39) | PIK3CAHCRTR1HCRTR2HSD11B1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |