Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4274570 | 0.74 | GAA (0.47) | GAASMN1; SMN2MEN1KMT2ACA12 | |
| SCHEMBL13766485 | 0.74 | GAA (0.47) | GAASMN1; SMN2MEN1KMT2ACA12 | |
| SCHEMBL9432347 | 0.74 | GAA (0.47) | GAASMN1; SMN2MEN1KMT2ACA12 | |
| SCHEMBL19068215 | 0.74 | GAA (0.47) | GAASMN1; SMN2MEN1KMT2ACA12 | |
| Hydrochloric Acid SCHEMBL4280057 | 0.72 | GAA (0.50) | GAASMN1; SMN2MEN1KMT2ACA12 | |
| Hydrochloric Acid SCHEMBL1964942 | 0.72 | GAA (0.50) | GAASMN1; SMN2MEN1KMT2ACA12 | |
| Hydrochloric Acid SCHEMBL1963623 | 0.72 | GAA (0.50) | GAASMN1; SMN2MEN1KMT2ACA12 | |
| SCHEMBL10922476 | 0.71 | CA12 (0.43) | MEN1KMT2ACA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL1967010 | 0.71 | GAA (0.49) | GAASMN1; SMN2MEN1KMT2ACA12 | |
| Hydrochloric Acid SCHEMBL1966105 | 0.71 | GAA (0.49) | GAASMN1; SMN2MEN1KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737854-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100351-A1 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | ASTRAZENECA AB (SE) | 2005-10-27 | — | — | WO | disclosed |