Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.74 |
| ▸ | AKT1 | P31749 | 19/20 | 0.68 |
| ▸ | AKT2 | P31751 | 12/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12759353 | 0.88 | KCNH2 (0.72) | KCNH2AKT1AKT2 | |
| SCHEMBL1059047 | 0.88 | KCNH2 (0.76) | KCNH2AKT1AKT2 | |
| Hydrochloric Acid SCHEMBL1501644 | 0.87 | KCNH2 (0.75) | KCNH2AKT1AKT2 | |
| SCHEMBL1501575 | 0.86 | KCNH2 (0.72) | KCNH2AKT1AKT2 | |
| SCHEMBL1501729 | 0.86 | KCNH2 (0.71) | KCNH2AKT1AKT2 | |
| SCHEMBL1501594 | 0.85 | KCNH2 (0.77) | KCNH2AKT1AKT2 | |
| SCHEMBL12759299 | 0.85 | KCNH2 (0.72) | KCNH2AKT1AKT2 | |
| SCHEMBL1501787 | 0.84 | KCNH2 (0.71) | KCNH2AKT1AKT2 | |
| SCHEMBL1501571 | 0.84 | KCNH2 (0.71) | KCNH2AKT1AKT2 | |
| SCHEMBL1501768 | 0.84 | KCNH2 (0.68) | KCNH2AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827436-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006065601-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2006-06-22 | — | — | WO | disclosed |