SCHEMBL5499571

SCHEMBL5499571

O=C(O)[CH]COCc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.54
HCAR2 Q8TDS4 1/20 0.50
ALDH1A1 P00352 4/20 0.47
MAPK1 P28482 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
SLC6A2 P23975 1/20 0.46
SLC6A3 Q01959 1/20 0.46
KMT2A Q03164 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
ALOX5 P09917 1/20 0.45
CA1 P00915 3/20 0.44
LMNA P02545 3/20 0.43
SLC1A1 P43005 1/20 0.42
CA2 P00918 2/20 0.42
CA9 Q16790 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MAPT P10636 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
CA7 P43166 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6223018 0.81 HCAR2 (0.56) TSHRHCAR2ALDH1A1MAPK1L3MBTL1
SCHEMBL6223013 0.81 HCAR2 (0.56) TSHRHCAR2ALDH1A1MAPK1L3MBTL1
Fumaric Acid SCHEMBL1319836 0.79 HCAR2 (0.69) TSHRHCAR2ALDH1A1MAPK1L3MBTL1
Maleic Acid SCHEMBL1319832 0.79 HCAR2 (0.69) TSHRHCAR2ALDH1A1MAPK1L3MBTL1
SCHEMBL3581957 0.78 TSHR (0.42) TSHRHCAR2ALDH1A1MAPK1L3MBTL1
Acrylic Acid SCHEMBL4934932 0.78 TSHR (0.62) TSHRHCAR2ALDH1A1MAPK1L3MBTL1
SCHEMBL4045487 0.77 TSHR (0.50) TSHRHCAR2ALDH1A1MAPK1L3MBTL1
SCHEMBL76044 0.77 TSHR (0.61) TSHRHCAR2ALDH1A1MAPK1L3MBTL1
SCHEMBL30425720 0.77 TSHR (0.61) TSHRHCAR2ALDH1A1MAPK1L3MBTL1
SCHEMBL15153296 0.77 TSHR (0.61) TSHRHCAR2ALDH1A1MAPK1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101035771-A 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) JANSSEN PHARMACEUTICA NV (BE) 2007-09-12 CN claimed
EP-1776349-A2 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA N.V. (BE) 2007-04-25 EP claimed
WO-2006017836-A2 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA, N.V. (BE) 2006-02-16 WO claimed
CN-101035772-B 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) JANSSEN PHARMACEUTICA N.V. (BE) 2011-12-14 CN disclosed
CN-101035771-A 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) JANSSEN PHARMACEUTICA NV (BE) 2007-09-12 CN disclosed
CN-101035772-A 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) JANSSEN PHARMACEUTICA NV (BE) 2007-09-12 CN disclosed
EP-1789398-A1 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE) JANSSEN PHARMACEUTICA N.V. (BE) 2007-05-30 EP disclosed
EP-1776349-A2 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA N.V. (BE) 2007-04-25 EP disclosed
EP-1776350-A1 NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF ß-SECRETASE ( BACE ) JANSSEN PHARMACEUTICA N.V. (BE) 2007-04-25 EP disclosed
WO-2006024932-A1 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE) JANSSEN PHARMACEUTICA, N.V. (US) 2006-03-09 WO disclosed
WO-2006017844-A1 NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) JANSSEN PHARMACEUTICA, N.V. (BE) 2006-02-16 WO disclosed
WO-2006017836-A2 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA, N.V. (BE) 2006-02-16 WO disclosed
EP-0738157-B1 CONTRAST MEDIA FOR X-RAY AND MAGNETIC RESONANCE IMAGING AMERSHAM HEALTH AS (NO) 2003-04-02 EP disclosed
US-5725840-A Steroidal ester contrast media for x-ray and magnetic resonance imaging NYCOMED IMAGING AS (NO) 1998-03-10 US disclosed
EP-0637252-A1 NHR CONTRAST AGENTS COCKBAIN, Julian Roderick Michaelson (GB) 1995-02-08 EP disclosed
WO-1993021960-A1 NHR CONTRAST AGENTS NYCOMED IMAGING AS (NO) 1993-11-11 WO disclosed
EP-0563145-A1 CHELATING AGENTS NYCOMED AS (NO) 1993-10-06 EP disclosed
WO-1992011232-A1 CHELATING AGENTS NYCOMED IMAGING AS (NO) 1992-07-09 WO disclosed