Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCAT | P04180 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550163 | 1.00 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 | |
| SCHEMBL2700133 | 1.00 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 | |
| SCHEMBL550836 | 1.00 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 | |
| SCHEMBL550164 | 1.00 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 | |
| SCHEMBL2701622 | 1.00 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 | |
| SCHEMBL550221 | 1.00 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 | |
| SCHEMBL2700135 | 1.00 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 | |
| SCHEMBL550071 | 1.00 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 | |
| SCHEMBL550541 | 0.97 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 | |
| SCHEMBL550540 | 0.97 | LCAT (0.43) | LCATHRH3EPHX2HSD11B1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |
| EP-1812005-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006053024-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |