Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.68 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4813655 | 0.99 | HDAC6 (0.69) | HDAC6HDAC1HDAC2HDAC3HDAC10 | |
| SCHEMBL4400310 | 0.91 | HDAC6 (0.58) | HDAC6HDAC1HDAC2HDAC3HDAC10 | |
| SCHEMBL4809855 | 0.83 | HDAC2 (0.52) | HDAC6HDAC1HDAC2HDAC3HDAC10 | |
| SCHEMBL4817430 | 0.82 | HDAC3 (0.49) | HDAC6HDAC1HDAC2HDAC3HDAC10 | |
| Abexinostat SCHEMBL444280 | 0.81 | HDAC6 (1.00) | HDAC6HDAC1HDAC2HDAC3HDAC10 | |
| Abexinostat SCHEMBL29489677 | 0.81 | HDAC6 (1.00) | HDAC6HDAC1HDAC2HDAC3HDAC10 | |
| Abexinostat SCHEMBL14762281 | 0.80 | HDAC6 (1.00) | HDAC6HDAC1HDAC2HDAC3HDAC10 | |
| Abexinostat SCHEMBL29544306 | 0.80 | HDAC6 (1.00) | HDAC6HDAC1HDAC2HDAC3HDAC10 | |
| SCHEMBL5497869 | 0.78 | HDAC2 (0.49) | HDAC6HDAC1HDAC2HDAC3HDAC10 | |
| Abexinostat SCHEMBL29454805 | 0.76 | HDAC6 (0.82) | HDAC6HDAC1HDAC2HDAC3HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656348-B1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARM INC (US) | 2007-02-07 | — | — | EP | claimed |