Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23766673 | 0.84 | HTT (0.43) | ALDH1A1SMN1; SMN2KDM4EMMERAB9A | |
| SCHEMBL15271430 | 0.80 | MME (0.36) | ALDH1A1SMN1; SMN2KDM4EMMERAB9A | |
| SCHEMBL28101354 | 0.80 | MME (0.36) | ALDH1A1SMN1; SMN2KDM4EMMERAB9A | |
| SCHEMBL194101 | 0.78 | MME (0.41) | ALDH1A1SMN1; SMN2KDM4EMMERAB9A | |
| SCHEMBL194100 | 0.78 | MME (0.41) | ALDH1A1SMN1; SMN2KDM4EMMERAB9A | |
| SCHEMBL444915 | 0.78 | MME (0.41) | ALDH1A1SMN1; SMN2KDM4EMMERAB9A | |
| SCHEMBL12658356 | 0.77 | MME (0.42) | MMERAB9AACECPA1ACE2 | |
| SCHEMBL30682423 | 0.75 | TYR (0.35) | ALDH1A1SMN1; SMN2KDM4EMMERAB9A | |
| SCHEMBL962888 | 0.72 | MME (0.33) | MMERAB9AACECPA1ACE2 | |
| SCHEMBL962887 | 0.72 | MME (0.33) | MMERAB9AACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844022-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | Hanmi Pharm. Co., Ltd. (KR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006071017-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |