Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 13/20 | 0.63 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505314 | 0.84 | S1PR1 (0.60) | S1PR1S1PR4S1PR5S1PR3NPC1 | |
| SCHEMBL16844821 | 0.80 | S1PR1 (0.70) | S1PR1S1PR4S1PR5S1PR3NPC1 | |
| SCHEMBL5494597 | 0.79 | SMN1; SMN2 (0.61) | NPC1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL3456593 | 0.78 | S1PR1 (0.54) | S1PR1S1PR4S1PR5S1PR3NPC1 | |
| SCHEMBL2813593 | 0.78 | S1PR1 (1.00) | S1PR1NPC1SMN1; SMN2RAB9APOLB | |
| SCHEMBL3457539 | 0.77 | S1PR1 (0.53) | S1PR1S1PR4S1PR5S1PR3NPC1 | |
| SCHEMBL5433657 | 0.77 | S1PR1 (0.56) | S1PR1S1PR4S1PR5S1PR3NPC1 | |
| SCHEMBL4741601 | 0.75 | S1PR1 (0.52) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL28776656 | 0.75 | S1PR1 (0.54) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL3763954 | 0.75 | S1PR1 (0.77) | S1PR1S1PR4S1PR5S1PR3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625123-A4 | 3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS | MERCK & CO INC (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20060252741-A1 | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists | MERCK & CO., INC. | 2006-11-09 | — | — | US | disclosed |
| CN-1788008-A | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as S1P receptor agonists | MERCK & CO INC (US) | 2006-06-14 | — | — | CN | disclosed |
| EP-1625123-A2 | 3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2006-02-15 | — | — | EP | disclosed |
| WO-2004103279-A2 | 3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2004-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252741-A1 | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists | S1PR1, S1PR3, S1PR5 | S1PR1 1/4885S1PR4 5/4885S1PR5 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.