Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | FASN | P49327 | 4/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550214 | 1.00 | CRBN (0.47) | CRBNMAPTALDH1A1NPSR1DDB1 | |
| SCHEMBL551065 | 1.00 | CRBN (0.47) | CRBNMAPTALDH1A1NPSR1DDB1 | |
| SCHEMBL2699052 | 1.00 | CRBN (0.47) | CRBNMAPTALDH1A1NPSR1DDB1 | |
| SCHEMBL551066 | 1.00 | CRBN (0.47) | CRBNMAPTALDH1A1NPSR1DDB1 | |
| SCHEMBL2699057 | 1.00 | CRBN (0.47) | CRBNMAPTALDH1A1NPSR1DDB1 | |
| SCHEMBL551024 | 0.90 | CRBN (0.59) | CRBNMAPTALDH1A1DDB1PDE7A | |
| SCHEMBL551023 | 0.90 | CRBN (0.59) | CRBNMAPTALDH1A1DDB1PDE7A | |
| SCHEMBL2699725 | 0.90 | CRBN (0.59) | CRBNMAPTALDH1A1DDB1PDE7A | |
| SCHEMBL550039 | 0.90 | CRBN (0.59) | CRBNMAPTALDH1A1DDB1PDE7A | |
| SCHEMBL2699729 | 0.90 | CRBN (0.59) | CRBNMAPTALDH1A1DDB1PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |