Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 12/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 12/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501264 | 0.84 | MAPK14 (0.59) | ADRA2AMCHR1MAPK14LCKKIT | |
| SCHEMBL5498385 | 0.76 | MAPK14 (0.72) | MAPK14LCKKITKDRMAPK9 | |
| SCHEMBL5496991 | 0.73 | MAPK14 (0.57) | MAPK14LCKKITKDRMAPK9 | |
| SCHEMBL5491723 | 0.71 | MAPK14 (0.70) | MAPK14LCKKITKDRMAPK9 | |
| SCHEMBL14715602 | 0.71 | MAPK14 (0.69) | MAPK14LCKKITKDRMAPK9 | |
| SCHEMBL5494293 | 0.68 | MAPK14 (0.70) | MAPK14LCKKITKDRMAPK9 | |
| SCHEMBL5495687 | 0.68 | MAPK14 (0.70) | MAPK14LCKKITKDRMAPK9 | |
| SCHEMBL23998126 | 0.67 | MAPK14 (0.52) | ADRA2AMCHR1MAPK14LCKKIT | |
| SCHEMBL13797477 | 0.67 | MCHR1 (1.00) | ADRA2AMCHR1HRH1HTR2BADRA1A | |
| SCHEMBL6869416 | 0.67 | ATM (0.50) | MAPK14CSNK2A1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | AMGEN INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | MAP3K1, MAP3K5, MAP3K2 | ADRA2A 1551/4885MCHR1 3077/4885MAPK14 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.