Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.37 |
| ▸ | IL2 | P60568 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507754 | 0.92 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CCHEK1 | |
| SCHEMBL6390285 | 0.85 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL5479126 | 0.85 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL2265927 | 0.84 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CS1PR1 | |
| SCHEMBL5510203 | 0.83 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL5506282 | 0.83 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL5503762 | 0.83 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL5067976 | 0.83 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL5066758 | 0.83 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL29565987 | 0.82 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191413-A1 | Novel heterocycle-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors | ATLANTA PHARMA AG (DE) | 2007-08-16 | — | — | US | claimed |
| US-20070191413-A1 | Novel heterocycle-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors | ATLANTA PHARMA AG (DE) | 2007-08-16 | — | — | US | disclosed |
| EP-1812400-A1 | NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2007-08-01 | — | — | EP | disclosed |
| WO-2005090311-A1 | NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191413-A1 | Novel heterocycle-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors | PDE4A, PDE4B, PDE4C | PDE4D 4/4885PDE4A 1/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.