SCHEMBL5503608

SCHEMBL5503608

CCOC(O)n1cnc2c(=O)[nH]c(N)nc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 9/20 0.56
MEN1 O00255 3/20 0.54
KMT2A Q03164 3/20 0.54
BLM P54132 2/20 0.54
ALDH1A1 P00352 1/20 0.54
LMNA P02545 1/20 0.54
CYP3A4 P08684 1/20 0.54
NFKB1 P19838 1/20 0.54
VCP P55072 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
HIF1A Q16665 1/20 0.54
PNP P00491 2/20 0.50
USP2 O75604 1/20 0.50
TSHR P16473 1/20 0.50
EDNRA P25101 1/20 0.50
HTR2A P28223 1/20 0.50
RECQL P46063 1/20 0.50
HBB P68871 1/20 0.50
HSD17B10 Q99714 1/20 0.50
TK1 P04183 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8630516 0.86 MEN1 (0.59) HPRT1MEN1KMT2ABLMALDH1A1
SCHEMBL28066642 0.83 HPRT1 (0.56) HPRT1MEN1KMT2ABLMALDH1A1
SCHEMBL19662085 0.83 HPRT1 (0.56) HPRT1MEN1KMT2ABLMALDH1A1
SCHEMBL9364021 0.82 MEN1 (0.54) HPRT1MEN1KMT2ABLMALDH1A1
SCHEMBL6455102 0.81 HPRT1 (0.56) HPRT1MEN1KMT2ABLMALDH1A1
SCHEMBL7815960 0.81 HPRT1 (0.54) HPRT1MEN1KMT2ABLMALDH1A1
SCHEMBL19258972 0.81 MEN1 (0.47) HPRT1MEN1KMT2ABLMALDH1A1
SCHEMBL17490593 0.81 POLG (0.69) HPRT1BLMPNPUSP2TSHR
SCHEMBL21311340 0.80 HPRT1 (0.61) HPRT1MEN1KMT2ABLMALDH1A1
SCHEMBL23710626 0.80 HPRT1 (0.53) HPRT1MEN1KMT2ABLMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105121068-A Particle functionalization UNIV MINNESOTA 2015-12-02 CN disclosed
EP-1819373-A2 COATINGS WITH CRYSTALLIZED ACTIVE AGENT(S) SurModics, Inc. (US) 2007-08-22 EP disclosed
WO-2006063021-A2 COATNGS WITH CRYSTALLIZED ACTIVE AGENTS (S) SURMODICS, INC. (US) 2006-06-15 WO disclosed
EP-1137764-B1 NEW MEDICAL USE OF GENE AND VECTOR ENCODING A MULTISUBSTRATE DEOXYRIBONUCLEOSIDASE ZGENE AS (DK) 2005-03-02 EP disclosed
US-6582947-B1 Nucleotide sequences coding enzymatic polypeptide for use in the virus treatment of cancer and viral infection BIO VICI (CH) 2003-06-24 US disclosed
EP-1137764-A1 NEW MEDICAL USE OF GENE AND VECTOR ENCODING A MULTISUBSTRATE DEOXYRIBONUCLEOSIDASE Biovici (CH) 2001-10-04 EP disclosed
WO-2000036099-A1 NEW MEDICAL USE OF GENE AND VECTOR ENCODING A MULTISUBSTRATE DEOXYRIBONUCLEOSIDASE BIOVICI (CH) 2000-06-22 WO disclosed
CN-86106534-A Carbocyclic purine nucleosides, its preparation and purposes 1987-05-27 CN disclosed