Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699639 | 1.00 | KDM4E (0.44) | KDM4ERECQLALDH1A1MAPTNPSR1 | |
| SCHEMBL550028 | 1.00 | KDM4E (0.44) | KDM4ERECQLALDH1A1MAPTNPSR1 | |
| SCHEMBL550373 | 1.00 | KDM4E (0.44) | KDM4ERECQLALDH1A1MAPTNPSR1 | |
| SCHEMBL550027 | 1.00 | KDM4E (0.44) | KDM4ERECQLALDH1A1MAPTNPSR1 | |
| SCHEMBL2699645 | 1.00 | KDM4E (0.44) | KDM4ERECQLALDH1A1MAPTNPSR1 | |
| SCHEMBL3699640 | 0.91 | PDE7A (0.39) | KDM4EALDH1A1MAPTPDE7AHRH3 | |
| SCHEMBL2697416 | 0.91 | PDE7A (0.39) | KDM4EALDH1A1MAPTPDE7AHRH3 | |
| SCHEMBL3699636 | 0.91 | PDE7A (0.39) | KDM4EALDH1A1MAPTPDE7AHRH3 | |
| SCHEMBL2697412 | 0.91 | PDE7A (0.39) | KDM4EALDH1A1MAPTPDE7AHRH3 | |
| SCHEMBL549753 | 0.90 | KDM4E (0.51) | KDM4ERECQLALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |