Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | LCAT | P04180 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2700970 | 1.00 | KDM4E (0.46) | KDM4ERECQLLCATDPP4DPP8 | |
| SCHEMBL2700968 | 1.00 | KDM4E (0.46) | KDM4ERECQLLCATDPP4DPP8 | |
| SCHEMBL550493 | 1.00 | KDM4E (0.46) | KDM4ERECQLLCATDPP4DPP8 | |
| SCHEMBL550262 | 1.00 | KDM4E (0.46) | KDM4ERECQLLCATDPP4DPP8 | |
| SCHEMBL550492 | 1.00 | KDM4E (0.46) | KDM4ERECQLLCATDPP4DPP8 | |
| SCHEMBL550263 | 1.00 | KDM4E (0.46) | KDM4ERECQLLCATDPP4DPP8 | |
| SCHEMBL551149 | 0.97 | KDM4E (0.47) | KDM4ERECQLLCATDPP4DPP8 | |
| SCHEMBL551148 | 0.97 | KDM4E (0.47) | KDM4ERECQLLCATDPP4DPP8 | |
| SCHEMBL2699509 | 0.92 | KDM4E (0.45) | KDM4ERECQLLCATDPP4DPP8 | |
| SCHEMBL550739 | 0.92 | KDM4E (0.45) | KDM4ERECQLLCATDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |