Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504241 | 1.00 | TDP1 (0.37) | TDP1MAPTLMNACYP3A4KDM4E | |
| SCHEMBL5505647 | 0.94 | TDP1 (0.38) | TDP1MAPTLMNACYP3A4KDM4E | |
| SCHEMBL5505652 | 0.94 | TDP1 (0.38) | TDP1MAPTLMNACYP3A4KDM4E | |
| SCHEMBL5507229 | 0.94 | TDP1 (0.36) | TDP1MAPTLMNACYP3A4KDM4E | |
| SCHEMBL5507217 | 0.94 | TDP1 (0.36) | TDP1MAPTLMNACYP3A4KDM4E | |
| SCHEMBL5506800 | 0.93 | TDP1 (0.37) | TDP1MAPTLMNACYP3A4KDM4E | |
| SCHEMBL5504896 | 0.93 | TDP1 (0.37) | TDP1MAPTLMNACYP3A4KDM4E | |
| SCHEMBL5502344 | 0.92 | TDP1 (0.34) | TDP1MAPTLMNACYP3A4KDM4E | |
| SCHEMBL5502352 | 0.92 | TDP1 (0.34) | TDP1MAPTLMNACYP3A4KDM4E | |
| SCHEMBL5510566 | 0.92 | TDP1 (0.35) | TDP1MAPTLMNACYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841339-B1 | Vinylpyrrolidinon cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| US-6294668-B1 | ANTIBACTERIAL ACTIVITY AGAINST BETA-LACTAM SENSITIVE AND RESISTANT GRAM-POSITIVE BACTERIA, SUCH AS STAPHYLOCOCCI, PNEUMOCOCCI, AND ENTEROCOCCI; USED IN THERAPY OF INFECTIOUS DISEASES CAUSED BY THOSE BACTERIA | HOFFMAN-LA ROCHE INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0841339-A1 | Vinylpyrrolidinon cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | disclosed |