Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.66 |
| ▸ | BCR | P11274 | 12/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.66 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL716834 | 0.96 | ABL1 (0.69) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL716774 | 0.94 | ABL1 (0.73) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL717539 | 0.92 | GAA (0.62) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL715934 | 0.90 | GAA (0.65) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL716887 | 0.89 | ABL1 (0.65) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL718498 | 0.88 | ABL1 (0.70) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL14586437 | 0.88 | ABL1 (0.72) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL10082544 | 0.87 | ABL1 (0.71) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL14286283 | 0.87 | ABL1 (0.71) | ABL1BCRPDGFRBHDAC3KDR | |
| SCHEMBL14030536 | 0.87 | ABL1 (0.65) | ABL1BCRPDGFRBHDAC3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758654-A1 | USE OF C-KIT INHIBITORS FOR TREATING PLASMODIUM RELATED DISEASES | AB Science (FR) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005115304-A2 | USE OF C-KIT INHIBITORS FOR TREATING FIBRODYSPLASIA | AB SCIENCE (FR) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005115385-A1 | USE OF C-KIT INHIBITORS FOR TREATING ACNE | AB SCIENCE (FR) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005102455-A1 | USE OF C-KIT INHIBITORS FOR TREATING PLASMODIUM RELATED DISEASES | AB SCIENCE (FR) | 2005-11-03 | — | — | WO | disclosed |