Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499767 | 0.81 | GBA1 (0.58) | GBA1MEN1KMT2AALDH1A1ATM | |
| SCHEMBL5503652 | 0.79 | GBA1 (0.56) | GBA1MEN1KMT2AALDH1A1ATM | |
| SCHEMBL7202401 | 0.78 | KMT2A (0.43) | MEN1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL16831309 | 0.75 | GBA1 (0.68) | GBA1MEN1KMT2AALDH1A1ATM | |
| SCHEMBL16831311 | 0.75 | GBA1 (0.68) | GBA1MEN1KMT2AALDH1A1ATM | |
| SCHEMBL16831398 | 0.75 | GBA1 (0.68) | GBA1MEN1KMT2AALDH1A1ATM | |
| SCHEMBL31494043 | 0.75 | GBA1 (0.68) | GBA1MEN1KMT2AALDH1A1ATM | |
| SCHEMBL15621005 | 0.74 | GBA1 (0.63) | GBA1MEN1KMT2AALDH1A1ATM | |
| SCHEMBL3264272 | 0.74 | GBA1 (0.47) | GBA1MEN1KMT2AALDH1A1ATM | |
| SCHEMBL16832012 | 0.71 | GBA1 (0.76) | GBA1MEN1KMT2AALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549306-A4 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2007-06-06 | — | — | EP | claimed |
| EP-1549306-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2005-07-06 | — | — | EP | claimed |
| WO-2003103660-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2003-12-18 | — | — | WO | claimed |