Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 16/20 | 0.62 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860187 | 0.87 | S1PR1 (0.60) | S1PR1S1PR3CACNA1GCACNA1HCACNA1I | |
| SCHEMBL12214248 | 0.84 | S1PR1 (0.54) | S1PR1S1PR3 | |
| SCHEMBL1854595 | 0.83 | S1PR1 (0.55) | S1PR1S1PR3CACNA1GCACNA1HCACNA1I | |
| SCHEMBL1858060 | 0.83 | S1PR1 (0.55) | S1PR1S1PR3CACNA1GCACNA1HCACNA1I | |
| SCHEMBL12663307 | 0.81 | S1PR1 (0.54) | S1PR1S1PR3 | |
| SCHEMBL1857565 | 0.77 | S1PR1 (0.54) | S1PR1S1PR3CACNA1GCACNA1HCACNA1I | |
| SCHEMBL1860941 | 0.77 | S1PR1 (0.54) | S1PR1S1PR3CACNA1GCACNA1HCACNA1I | |
| SCHEMBL1858069 | 0.77 | S1PR1 (1.00) | S1PR1S1PR3 | |
| SCHEMBL20892474 | 0.74 | S1PR1 (0.44) | S1PR1S1PR3 | |
| SCHEMBL2203828 | 0.74 | S1PR1 (1.00) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863787-A1 | HYDOGRENATED BENZO[C]THIOPHENE DERIVATIVES AS IMMUNOMODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006100631-A1 | HYDROGENATED BENZO (C) THIOPHENE DERIVATIVES AS IMMUNOMODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-09-28 | — | — | WO | disclosed |