Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2736370 | 1.00 | EGFR (0.56) | EGFRERBB2LCKHDAC3HDAC4 | |
| SCHEMBL2736391 | 0.93 | EGFR (0.52) | EGFRERBB2LCKHDAC3HDAC4 | |
| SCHEMBL5498832 | 0.93 | EGFR (0.52) | EGFRERBB2LCKHDAC3HDAC4 | |
| SCHEMBL2760199 | 0.92 | EGFR (0.68) | EGFRERBB2 | |
| SCHEMBL13946642 | 0.86 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL216073 | 0.85 | EGFR (0.56) | EGFRERBB2LCKHDAC3HDAC4 | |
| SCHEMBL214931 | 0.83 | EGFR (0.52) | EGFRERBB2LCKHDAC3HDAC4 | |
| SCHEMBL8305182 | 0.82 | EGFR (0.80) | EGFRERBB2LCK | |
| SCHEMBL216038 | 0.82 | EGFR (0.59) | EGFRERBB2LCKHDAC3HDAC4 | |
| SCHEMBL217990 | 0.82 | EGFR (0.68) | EGFRERBB2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567506-A4 | CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS | ARRAY BIOPHARMA INC (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1567506-A2 | CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS | Array Biopharma, Inc. (US) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004046101-A2 | CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS | ARRAY BIOPHARMA, INC. (US) | 2004-06-03 | — | — | WO | disclosed |