Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 9/20 | 0.61 |
| ▸ | PARP1 | P09874 | 3/20 | 0.55 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5512568 | 0.94 | GNRHR (0.63) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5511248 | 0.94 | GNRHR (0.63) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5507824 | 0.93 | GNRHR (0.62) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5508081 | 0.92 | GNRHR (0.61) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5999615 | 0.92 | GNRHR (0.61) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5506661 | 0.91 | GNRHR (0.59) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5509921 | 0.91 | GNRHR (0.61) | GNRHRPARP1DHODH | |
| SCHEMBL5510258 | 0.90 | GNRHR (0.59) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5509545 | 0.90 | GNRHR (0.59) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5502980 | 0.90 | GNRHR (0.61) | GNRHRPARP1DHODHDRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814866-A2 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006058012-A2 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | WYETH (US) | 2006-06-01 | — | — | WO | disclosed |