Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 3/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.52 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL710200 | 0.99 | CARM1 (0.51) | CARM1PRMT6SLC6A9KCNH2CYP2D6 | |
| SCHEMBL708522 | 0.90 | CARM1 (0.50) | CARM1PRMT6SLC6A9KCNH2DRD4 | |
| SCHEMBL5512185 | 0.89 | CARM1 (0.48) | CARM1PRMT6SLC6A9KCNH2GRM2 | |
| SCHEMBL5512497 | 0.89 | CARM1 (0.50) | CARM1PRMT6SLC6A9KCNH2CYP2D6 | |
| SCHEMBL3775184 | 0.88 | CARM1 (0.54) | CARM1PRMT6SLC6A9KCNH2CYP2D6 | |
| SCHEMBL5510226 | 0.88 | CARM1 (0.48) | CARM1PRMT6SLC6A9KCNH2CYP2D6 | |
| SCHEMBL5512694 | 0.88 | CARM1 (0.49) | CARM1PRMT6SLC6A9KCNH2CYP2D6 | |
| SCHEMBL5509517 | 0.87 | CARM1 (0.52) | CARM1PRMT6SLC6A9KCNH2CYP2D6 | |
| SCHEMBL15967077 | 0.87 | CARM1 (0.47) | CARM1PRMT6SLC6A9KCNH2CYP2D6 | |
| SCHEMBL5510881 | 0.87 | CARM1 (0.53) | CARM1PRMT6SLC6A9KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |