Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 20/20 | 0.58 |
| ▸ | NR1H3 | Q13133 | 16/20 | 0.58 |
| ▸ | PPARG | P37231 | 3/20 | 0.54 |
| ▸ | PPARD | Q03181 | 3/20 | 0.54 |
| ▸ | PPARA | Q07869 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508555 | 0.90 | NR1H2 (0.56) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL28769033 | 0.89 | NR1H2 (0.56) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL5505556 | 0.88 | NR1H2 (0.53) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL3278045 | 0.86 | NR1H2 (0.57) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL3279593 | 0.86 | NR1H2 (0.68) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL3279446 | 0.84 | NR1H2 (0.58) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27673882 | 0.83 | NR1H2 (0.78) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL3279777 | 0.83 | NR1H2 (0.56) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27673876 | 0.83 | NR1H2 (0.79) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL3282473 | 0.82 | NR1H2 (0.64) | NR1H2NR1H3PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101166730-A | Cinnoline compounds and their use as liver X receptor modilators | WYETH CORP (US) | 2008-04-23 | — | — | CN | claimed |
| CN-101166730-A | Cinnoline compounds and their use as liver X receptor modilators | WYETH CORP (US) | 2008-04-23 | — | — | CN | disclosed |
| EP-1853566-A1 | CINNOLINE COMPOUNDS AND THEIR USE AS LIVER X RECEPTOR MODULATORS | Wyeth (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006094034-A1 | CINNOLINE COMPOUNDS AND THEIR USE AS LIVER X RECEPTOR MODILATORS | WYETH (US) | 2006-09-08 | — | — | WO | disclosed |