SCHEMBL5508404

SCHEMBL5508404

CCc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1ccc(CCC(=O)O)c(C)c1

nearest known ligand 0.82

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 17/20 0.82
PPARA Q07869 11/20 0.82
PPARG P37231 8/20 0.82
FFAR1 O14842 5/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5508401 0.94 PPARD (0.81) PPARDPPARAPPARGFFAR1
SCHEMBL5514653 0.92 PPARD (0.78) PPARDPPARAPPARGFFAR1
SCHEMBL5516718 0.91 PPARD (0.79) PPARDPPARAPPARGFFAR1
SCHEMBL5511968 0.91 PPARD (0.79) PPARDPPARAPPARGFFAR1
SCHEMBL5509797 0.91 PPARD (0.78) PPARDPPARAPPARGFFAR1
SCHEMBL6238901 0.90 PPARD (1.00) PPARDPPARAPPARGFFAR1
SCHEMBL5526130 0.90 PPARD (0.66) PPARDPPARAPPARGFFAR1
SCHEMBL5509827 0.88 PPARD (0.73) PPARDPPARAPPARGFFAR1
SCHEMBL5517534 0.87 PPARD (0.79) PPARDPPARAPPARGFFAR1
SCHEMBL4674733 0.87 PPARD (0.72) PPARDPPARAPPARGFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060084663-A1 Peroxisome proliferator activated receptor modulators ELI LILLY AND COMPANY, PATENT DIVISION (US) 2006-04-20 US claimed
US-7259175-B2 Peroxisome proliferator activated receptor modulators ELI LILLY AND COMPANY (US) 2007-08-21 US disclosed
US-7259175-B2 Peroxisome proliferator activated receptor modulators ELI LILLY AND COMPANY (US) 2007-08-21 US disclosed
US-7259175-B2 Peroxisome proliferator activated receptor modulators ELI LILLY AND COMPANY (US) 2007-08-21 US disclosed
US-20060084663-A1 Peroxisome proliferator activated receptor modulators ELI LILLY AND COMPANY, PATENT DIVISION (US) 2006-04-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060084663-A1 Peroxisome proliferator activated receptor modulators PPARG, PPARA, PPARD PPARD 3/4885PPARA 2/4885PPARG 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.