⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL969257 | 1.00 | — | — | |
| SCHEMBL13563 | 1.00 | — | — | |
| SCHEMBL28281550 | 0.95 | OR51E2 (0.35) | — | |
| SCHEMBL440539 | 0.92 | — | — | |
| SCHEMBL540667 | 0.90 | — | — | |
| SCHEMBL28580896 | 0.90 | CA1 (0.39) | — | |
| SCHEMBL4198 | 0.82 | — | — | |
| SCHEMBL969300 | 0.82 | — | — | |
| SCHEMBL80643 | 0.82 | — | — | |
| SCHEMBL4621927 | 0.82 | FABP6 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174537-B1 | MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN | MERCK SHARP & DOHME (US) | 2021-06-23 | — | — | EP | claimed |
| EP-3027619-B1 | BICYCLIC UREAS AND THIADIAZOLIDINE-1,1-DIOXIDES AS CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2019-01-02 | — | — | EP | claimed |
| EP-3083642-B1 | FUSED BICYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN | MERCK SHARP & DOHME (US) | 2018-09-05 | — | — | EP | claimed |
| US-10011572-B2 | Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein | MERCK SHARP & DOHME CORP. (US) | 2018-07-03 | — | — | US | claimed |
| US-9981970-B2 | Bicyclic ureas and thiadiazolidine-1, 1-dioxides as CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-05-29 | — | — | US | claimed |
| EP-3322420-A1 | BICYCLIC HETEROCYCLES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN | Merck Sharp & Dohme Corp. (US) | 2018-05-23 | — | — | EP | claimed |
| EP-2928881-B1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-03-14 | — | — | EP | claimed |
| US-20170210715-A1 | MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN | MERCK SHARP & DOHME CORP. (US) | 2017-07-27 | — | — | US | claimed |
| EP-3174537-A1 | MONOCYCLIC ISOXAZOLINES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN | Merck Sharp & Dohme Corp. (US) | 2017-06-07 | — | — | EP | claimed |
| US-9663534-B2 | Fused bicyclic isoxazolines as inhibitors of cholesterol ester transfer protein | MERCK SHARP & DOHME CORP. (US) | 2017-05-30 | — | — | US | claimed |
| WO-2013128028-A1 | PYRAZOLO - TRIAZINE DERIVATIVES AS SELECTIVE CYCLIN- DEPENDENT KINASE INHINITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2013-09-06 | — | — | WO | claimed |
| EP-2634190-A1 | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors | Lead Discovery Center GmbH (DE) | 2013-09-04 | — | — | EP | claimed |
| EP-2634189-A1 | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors | Lead Discovery Center GmbH (DE) | 2013-09-04 | — | — | EP | claimed |
| WO-2013063217-A1 | FUSED BICYCLIC OXAZOLIDINONE CETP INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | claimed |
| US-20130109649-A1 | FUSED BICYCLIC OXAZOLIDINONE CETP INHIBITOR | MERCK SHARP & DOHME LLC | 2013-05-02 | — | — | US | claimed |
| US-20120316147-A1 | NOVEL PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-12-13 | — | — | US | claimed |
| EP-2450351-A1 | Lactam compounds and their use as pharmaceuticals | Incyte Corporation (US) | 2012-05-09 | — | — | EP | claimed |
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |
| US-20090291946-A1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2009-11-26 | — | — | US | claimed |
| US-20060116382-A1 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2006-06-01 | — | — | US | claimed |