Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.82 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1449746 | 0.91 | ADORA2A (0.69) | ADORA2AADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL1449367 | 0.90 | ADORA2A (0.83) | ADORA2AADORA1ALDH1A1CYP1A2CYP2C9 | |
| Cyclohexane SCHEMBL15484642 | 0.89 | ADORA2A (0.79) | ADORA2AADORA1ALDH1A1MAPTCYP1A2 | |
| Cyclopropane SCHEMBL15484716 | 0.89 | ADORA2A (0.79) | ADORA2AADORA1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL1449376 | 0.88 | ADORA2A (0.77) | ADORA2AADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL1449994 | 0.87 | ADORA2A (1.00) | ADORA2AADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL1449674 | 0.86 | ADORA2A (0.62) | ADORA2AADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL1449374 | 0.85 | ADORA2A (0.91) | ADORA2AADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL1449335 | 0.85 | ADORA2A (0.81) | ADORA2AADORA1ALDH1A1MEN1KMT2A | |
| SCHEMBL1449976 | 0.84 | ADORA2A (0.80) | ADORA2AADORA1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794157-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVES | H.Lundbeck A/S (DK) | 2007-06-13 | — | — | EP | claimed |
| WO-2006032273-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2006-03-30 | — | — | WO | claimed |
| EP-1794157-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2014-02-26 | — | — | EP | disclosed |