Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.44 |
| ▸ | CETP | P11597 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511194 | 0.92 | MAPK14 (0.49) | BACE1BCHEACHEDRD4CARM1 | |
| SCHEMBL712568 | 0.92 | BACE1 (0.48) | BACE1BCHEACHEDRD4CARM1 | |
| SCHEMBL708522 | 0.91 | CARM1 (0.50) | BACE1BCHEACHEDRD4CARM1 | |
| SCHEMBL5512185 | 0.90 | CARM1 (0.48) | BACE1BCHEACHEDRD4CARM1 | |
| SCHEMBL5514659 | 0.90 | CARM1 (0.46) | BACE1BCHEACHEDRD4CARM1 | |
| SCHEMBL5510930 | 0.90 | CARM1 (0.46) | BACE1BCHEACHEDRD4CARM1 | |
| SCHEMBL708602 | 0.89 | CARM1 (0.45) | BACE1BCHEACHEDRD4CARM1 | |
| SCHEMBL15967011 | 0.89 | CARM1 (0.48) | BACE1BCHEACHEDRD4CARM1 | |
| SCHEMBL5513313 | 0.88 | CARM1 (0.47) | BACE1BCHEACHEDRD4CARM1 | |
| SCHEMBL5506387 | 0.88 | HDAC3 (0.46) | BACE1BCHEACHEDRD4CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |