Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 16/20 | 0.44 |
| ▸ | PTPRF | P10586 | 1/20 | 0.42 |
| ▸ | PTPRA | P18433 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2950951 | 0.86 | PTPN1 (0.59) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL2947341 | 0.79 | PTPN1 (0.69) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL2943848 | 0.78 | PPARG (0.46) | PTPN1PPARGPPARA | |
| SCHEMBL2944742 | 0.78 | PTPN1 (0.41) | PTPN1PTGS2PPARGPPARANPC1 | |
| SCHEMBL2951909 | 0.77 | F2RL3 (0.42) | PTPN1PTGS2PPARGPPARA | |
| SCHEMBL2951293 | 0.70 | PPARG (0.47) | PTPN1PPARGPPARA | |
| SCHEMBL7497974 | 0.70 | PTPN1 (0.81) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL7506773 | 0.69 | PTPN1 (0.82) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL2950936 | 0.69 | PPARG (0.59) | PTPN1PTPRFPTPRAPTPN7DUSP3 | |
| SCHEMBL2941632 | 0.69 | NR1H4 (0.49) | PTPN1PTPN7NPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781645-A1 | OXAZOLO-NAPHTHYL ACIDS AS PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1(PAI-1) MODULATORS USEFUL IN THE TREATMENT OF THROMBOSIS AND CARDIOVASCULAR DISEASES | Wyeth (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006023865-A1 | OXAZOLO-NAPHTHYL ACIDS AS PLAMINOGEN ACTIVATOR INHIBTOR TYPE-1 (PAI-1) MODULATORS USEFUL IN THE TREATMENT OF THROMBOSIS AND CARDIOVASCULAR DISEASES | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |