Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348393 | 0.94 | MEN1 (0.52) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3423309 | 0.91 | MEN1 (0.55) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3419906 | 0.91 | MEN1 (0.52) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3350749 | 0.90 | MEN1 (0.49) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3347951 | 0.89 | MAPT (0.48) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3352762 | 0.88 | MEN1 (0.53) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3351930 | 0.88 | MEN1 (0.48) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3423179 | 0.87 | MEN1 (0.50) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3423004 | 0.87 | MEN1 (0.54) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3348196 | 0.86 | MEN1 (0.49) | MEN1KMT2AALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851230-A1 | TETRAHYDROPYRIDOTHIOPHENES AS ANTRIPOLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER | Nycomed GmbH (DE) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006084904-A1 | TETRAHYDROPYRIDOTHIOPHENES AS ANTRIPOLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER | NYCOMED GMBH (DE) | 2006-08-17 | — | — | WO | disclosed |