Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5509960 | 0.89 | HRH3 (0.67) | HRH3KDM4EPDE10ACCR2TDP1 | |
| SCHEMBL3578596 | 0.84 | HRH3 (0.68) | HRH3KDM4EPDE10ACCR2TDP1 | |
| SCHEMBL3583820 | 0.83 | HRH3 (0.67) | HRH3KDM4EPDE10ACCR2TDP1 | |
| SCHEMBL13807075 | 0.82 | HRH3 (0.95) | HRH3KDM4EPDE10ACCR2TDP1 | |
| Hydrochloric Acid SCHEMBL3591350 | 0.82 | HRH3 (0.65) | HRH3KDM4EPDE10ACCR2TDP1 | |
| SCHEMBL3586113 | 0.81 | HRH3 (0.65) | HRH3KDM4EPDE10ACCR2TDP1 | |
| Hydrochloric Acid SCHEMBL3580508 | 0.81 | HRH3 (0.63) | HRH3KDM4EPDE10ACCR2TDP1 | |
| SCHEMBL3578418 | 0.80 | HRH3 (0.67) | HRH3KDM4EPDE10ACCR2TDP1 | |
| SCHEMBL13503458 | 0.80 | HRH3 (0.69) | HRH3KDM4EPDE10ACCR2TDP1 | |
| SCHEMBL3585423 | 0.78 | HRH3 (0.67) | HRH3KDM4EPDE10ACCR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786790-A1 | OXAZOLE DERIVATIVES AS HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006019833-A1 | OXAZOLE DERIVATIVES AS HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-02-23 | — | — | WO | disclosed |