Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 3/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.44 |
| ▸ | CETP | P11597 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967210 | 0.93 | CARM1 (0.45) | CARM1PRMT6CETPDRD4HCRTR1 | |
| SCHEMBL708522 | 0.88 | CARM1 (0.50) | CARM1PRMT6DRD4HCRTR1HCRTR2 | |
| SCHEMBL5511421 | 0.87 | CARM1 (0.43) | CARM1PRMT6CETPDRD4HCRTR1 | |
| SCHEMBL5510541 | 0.87 | CARM1 (0.43) | CARM1PRMT6CETPDRD4HCRTR1 | |
| SCHEMBL710204 | 0.87 | CXCR4 (0.45) | CARM1PRMT6DRD4HCRTR1HCRTR2 | |
| SCHEMBL5510247 | 0.86 | CARM1 (0.46) | CARM1PRMT6DRD4SLC6A9KCNH2 | |
| SCHEMBL5517990 | 0.85 | CARM1 (0.43) | CARM1PRMT6CETPDRD4SLC6A9 | |
| SCHEMBL15967075 | 0.85 | CARM1 (0.43) | CARM1PRMT6CETPHCRTR1HCRTR2 | |
| SCHEMBL5514667 | 0.85 | CARM1 (0.46) | CARM1PRMT6CETPDRD4SLC6A9 | |
| SCHEMBL5514659 | 0.85 | CARM1 (0.46) | CARM1PRMT6CETPDRD4HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |