Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2700906 | 1.00 | MAPT (0.38) | MAPTPIK3CAHSD11B1CRBNDDB1 | |
| SCHEMBL554628 | 1.00 | MAPT (0.38) | MAPTPIK3CAHSD11B1CRBNDDB1 | |
| SCHEMBL554629 | 1.00 | MAPT (0.38) | MAPTPIK3CAHSD11B1CRBNDDB1 | |
| SCHEMBL2700902 | 1.00 | MAPT (0.38) | MAPTPIK3CAHSD11B1CRBNDDB1 | |
| SCHEMBL551044 | 1.00 | MAPT (0.38) | MAPTPIK3CAHSD11B1CRBNDDB1 | |
| SCHEMBL550340 | 0.88 | CRBN (0.41) | PIK3CAHSD11B1CRBNDDB1HRH3 | |
| SCHEMBL2700795 | 0.88 | CRBN (0.41) | PIK3CAHSD11B1CRBNDDB1HRH3 | |
| SCHEMBL549661 | 0.88 | CRBN (0.41) | PIK3CAHSD11B1CRBNDDB1HRH3 | |
| SCHEMBL550339 | 0.88 | CRBN (0.41) | PIK3CAHSD11B1CRBNDDB1HRH3 | |
| SCHEMBL549662 | 0.88 | CRBN (0.41) | PIK3CAHSD11B1CRBNDDB1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |