Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 13/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982475 | 1.00 | PTGER4 (0.56) | PTGER4PTGER2LMNAPTGER1GPR139 | |
| SCHEMBL3981868 | 0.93 | PTGER4 (0.51) | PTGER4PTGER2LMNAPTGER1 | |
| SCHEMBL3982055 | 0.93 | PTGER4 (0.52) | PTGER4PTGER2LMNAALDH1A1KDM4E | |
| SCHEMBL5512186 | 0.93 | PTGER4 (0.52) | PTGER4PTGER2LMNAALDH1A1KDM4E | |
| SCHEMBL3987696 | 0.92 | PTGER4 (0.54) | PTGER4PTGER2LMNAPTGER1ALDH1A1 | |
| SCHEMBL690929 | 0.92 | PTGER4 (0.67) | PTGER4PTGER2 | |
| SCHEMBL3977110 | 0.91 | PTGER4 (0.55) | PTGER4PTGER2PTGER1GPR139ALDH1A1 | |
| SCHEMBL15463568 | 0.90 | PTGER4 (0.51) | PTGER4PTGER2LMNA | |
| SCHEMBL3982911 | 0.90 | PTGER4 (0.51) | PTGER4PTGER2LMNA | |
| SCHEMBL4013928 | 0.89 | PTGER4 (0.52) | PTGER4PTGER2LMNAPTGER1GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740211-A2 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005102389-A2 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-11-03 | — | — | WO | disclosed |