⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566523 | 0.59 | — | — | |
| SCHEMBL14438144 | 0.59 | — | — | |
| Methylsulfanylmethane SCHEMBL14352912 | 0.54 | — | — | |
| SCHEMBL9328851 | 0.54 | — | — | |
| Ethane SCHEMBL2058527 | 0.54 | — | — | |
| SCHEMBL159813 | 0.54 | — | — | |
| SCHEMBL22226 | 0.54 | — | — | |
| Methylsulfanylmethane SCHEMBL3444503 | 0.50 | — | — | |
| Methyl Alcohol SCHEMBL9067144 | 0.50 | — | — | |
| Methylsulfanylmethane SCHEMBL29540305 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253183-B2 | Method of use of (imidazol-5-yl)methyl-2-quinolinone derivatives to inhibit smooth muscle cell proliferation | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-07 | — | — | US | disclosed |
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1162201-B1 | Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2006-03-29 | — | — | EP | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |
| US-20040198771-A1 | Method of use of (imidazol-5-yl)methyl-2-quinolinone derivatives to inhibit smooth muscle cell proliferation | END DAVID WILLIAM (US) | 2004-10-07 | — | — | US | disclosed |
| US-6743805-B2 | TREATING VASCULAR PROLIFERATIVE DISORDERS | JANSSEN PHARMACEUTICA NV (BE) | 2004-06-01 | — | — | US | disclosed |
| US-6734194-B2 | TO PREVENT OR TREAT VASCULAR PROLIFERATIVE DISORDERS SUCH AS ATHEROSCLEROSIS AND RESTENOSIS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-05-11 | — | — | US | disclosed |
| US-20030229118-A1 | Method of use of (imidazol-5-yl)methyl-2-quinolinone derivatives to inhibit smooth muscle cell proliferation | END DAVID WILLIAM (US) | 2003-12-11 | — | — | US | disclosed |
| EP-0988038-B1 | (IMIDAZOL-5-YL)METHYL-2-QUINOLINONE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | JANSSEN PHARMACEUTICA NV (BE) | 2002-08-14 | — | — | EP | disclosed |
| EP-1162201-A2 | Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-12-12 | — | — | EP | disclosed |
| US-6294521-B1 | SUGAR PHOSPHATES | AUSTRALIAN NATIONAL UNIVERSITY (AU) | 2001-09-25 | — | — | US | disclosed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |
| WO-2001017516-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2001-03-15 | — | — | WO | disclosed |
| US-6169096-B1 | FOR INHIBITING TUMOR GROWTH IN A MAMMAL | JANSSEN PHARMACAEUTIC N.V. (BE) | 2001-01-02 | — | — | US | disclosed |
| EP-0988038-A1 | (IMIDAZOL-5-YL)METHYL-2-QUINOLINONE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-03-29 | — | — | EP | disclosed |
| US-6037350-A | USEFUL AS ANTICANCER AGENTS FOR TUMORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-03-14 | — | — | US | disclosed |
| WO-1998055124-A1 | (IMIDAZOL-5-YL)METHYL-2-QUINOLINONE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-12-10 | — | — | WO | disclosed |
| EP-0865440-A1 | FARNESYL PROTEIN TRANSFERASE INHIBITING (IMIDAZOL-5-YL)METHYL-2-QUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021701-A1 | FARNESYL PROTEIN TRANSFERASE INHIBITING (IMIDAZOL-5-YL)METHYL-2-QUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-06-19 | — | — | WO | disclosed |