Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 2/20 | 0.59 |
| ▸ | PTPN11 | Q06124 | 18/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976695 | 0.85 | SCN2A (0.62) | SCN2APTPN11MAPK1CYP2D6MAOA | |
| SCHEMBL2415435 | 0.78 | SCN2A (0.67) | SCN2APTPN11SCN10AKCNH2 | |
| SCHEMBL2421429 | 0.77 | SCN2A (0.57) | SCN2APTPN11MAPK1CYP2D6MAOA | |
| Elpetrigine SCHEMBL978547 | 0.75 | SCN2A (1.00) | SCN2APTPN11MAPK1CYP2D6MAOA | |
| SCHEMBL27776395 | 0.74 | AHR (0.41) | SCN2APTPN11MAPK1CYP2D6MAOA | |
| SCHEMBL2416231 | 0.72 | SCN2A (0.48) | SCN2APTPN11MAPK1CYP2D6MAOA | |
| SCHEMBL2415584 | 0.72 | SCN2A (0.51) | SCN2APTPN11MAPK1CYP2D6SCN5A | |
| SCHEMBL2415308 | 0.72 | SCN2A (0.48) | SCN2APTPN11MAPK1 | |
| SCHEMBL7059600 | 0.71 | MAPK1 (0.59) | SCN2APTPN11MAPK1CYP2D6MAOA | |
| SCHEMBL29542922 | 0.71 | MAPK1 (0.59) | SCN2APTPN11MAPK1CYP2D6MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853230-A2 | DOSAGE FORM AND METHOD FOR SUSTAINED RELEASE OF A SUBSTITUTED PYRAZINE COMPOUND | Jazz Pharmaceuticals Inc. (US) | 2007-11-14 | — | — | EP | claimed |
| WO-2006088814-A2 | DOSAGE FORM AND METHOD FOR SUSTAINED RELEASE OF A SUBSTITUTED PYRAZINE COMPOUND | JAZZ PHARMACEUTICALS (US) | 2006-08-24 | — | — | WO | claimed |