Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.69 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.69 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5994058 | 0.90 | PDE10A (0.72) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL4397682 | 0.89 | PDE10A (0.69) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL4397080 | 0.87 | PDE10A (0.65) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL4411887 | 0.87 | PDE10A (0.67) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL4403831 | 0.87 | PDE10A (0.67) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL4411881 | 0.86 | PDE10A (0.66) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL4401301 | 0.85 | PDE10A (0.68) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL5499004 | 0.85 | PDE10A (0.64) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL5509404 | 0.85 | PDE10A (0.64) | PDE10APDE3APDE3BACHEBACE1 | |
| Tetrahydrofuran SCHEMBL4409536 | 0.85 | PDE10A (0.64) | PDE10APDE3APDE3BACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838702-A1 | PYRROLIDYL DERIVATIVES OF HETEROAROMATIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | Pfizer Products Inc. (US) | 2007-10-03 | — | — | EP | claimed |
| WO-2006070284-A1 | PYRROLIDYL DERIVATIVES OF HETEROAROMATIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-07-06 | — | — | WO | claimed |