Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.49 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.49 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.49 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2057475 | 0.91 | TDP1 (0.73) | TDP1ESR2ESR1MAPK1NR1I2 | |
| SCHEMBL9462807 | 0.88 | TDP1 (0.69) | TDP1ESR2ESR1MAPK1NR1I2 | |
| SCHEMBL13267917 | 0.87 | MAPK1 (0.71) | TDP1ESR2ESR1MAPK1NR1I2 | |
| SCHEMBL1278659 | 0.86 | TDP1 (0.67) | TDP1ESR2ESR1MAPK1NR1I2 | |
| SCHEMBL27539525 | 0.85 | TDP1 (0.61) | TDP1ESR2ESR1MAPK1NR1I2 | |
| SCHEMBL3482729 | 0.85 | TDP1 (0.65) | TDP1ESR2ESR1MAPK1NR1I2 | |
| SCHEMBL579010 | 0.84 | TDP1 (0.64) | TDP1ESR2ESR1MAPK1NR1I2 | |
| SCHEMBL29173159 | 0.84 | TDP1 (0.64) | TDP1ESR2ESR1MAPK1NR1I2 | |
| SCHEMBL8349234 | 0.84 | TDP1 (0.64) | TDP1ESR2ESR1MAPK1NR1I2 | |
| SCHEMBL18763131 | 0.84 | TDP1 (0.64) | TDP1ESR2ESR1MAPK1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549306-A4 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2007-06-06 | — | — | EP | claimed |
| EP-1549306-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2005-07-06 | — | — | EP | claimed |
| WO-2003103660-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2003-12-18 | — | — | WO | claimed |