Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | CRHBP | P24387 | 1/20 | 0.65 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655224 | 0.89 | KMT2A (0.58) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL9917542 | 0.81 | MAPT (0.53) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL2555620 | 0.80 | MAPT (0.60) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL2555623 | 0.80 | MAPT (0.60) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL3279624 | 0.77 | POLB (0.50) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL3839304 | 0.75 | MAPT (0.54) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL3839303 | 0.75 | MAPT (0.54) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL6068417 | 0.73 | MEN1 (0.52) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL6068420 | 0.73 | MEN1 (0.52) | MAPTSMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL4104718 | 0.73 | MAPT (0.55) | MAPTSMN1; SMN2KMT2AHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853566-A1 | CINNOLINE COMPOUNDS AND THEIR USE AS LIVER X RECEPTOR MODULATORS | Wyeth (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006094034-A1 | CINNOLINE COMPOUNDS AND THEIR USE AS LIVER X RECEPTOR MODILATORS | WYETH (US) | 2006-09-08 | — | — | WO | disclosed |