Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 10/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5510727 | 0.89 | GNRHR (0.61) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5508021 | 0.87 | GNRHR (0.55) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5505241 | 0.87 | GNRHR (0.64) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5508028 | 0.86 | GNRHR (0.55) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5509131 | 0.85 | GNRHR (0.57) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5505197 | 0.85 | GNRHR (0.58) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5511248 | 0.85 | GNRHR (0.63) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5512342 | 0.84 | GNRHR (0.68) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL5999615 | 0.84 | GNRHR (0.61) | GNRHRPARP1DHODHDRD3DRD2 | |
| SCHEMBL6001622 | 0.84 | GNRHR (0.58) | GNRHRPARP1DHODHDRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814866-A2 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006058012-A2 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | WYETH (US) | 2006-06-01 | — | — | WO | disclosed |