Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2839927 | 0.86 | CYP2C9 (0.46) | CYP2C9CYP3A4CYP2C19KCNH2CACNA1C | |
| SCHEMBL2840204 | 0.84 | CYP2C9 (0.46) | CYP2C9CYP3A4CYP2C19KCNH2CACNA1C | |
| SCHEMBL14323627 | 0.83 | CYP2C9 (0.45) | CYP2C9CYP3A4CYP2C19KCNH2CACNA1C | |
| SCHEMBL2843902 | 0.83 | CYP2C9 (0.47) | CYP2C9CYP3A4CYP2C19KCNH2CACNA1C | |
| SCHEMBL2842699 | 0.81 | CYP2C9 (0.46) | CYP2C9CYP3A4CYP2C19KCNH2CACNA1C | |
| SCHEMBL5514943 | 0.80 | CYP3A4 (0.52) | CYP2C9CYP3A4CYP2C19KCNH2CACNA1C | |
| SCHEMBL2834892 | 0.80 | CYP3A4 (0.43) | CYP2C9CYP3A4CYP2C19KCNH2CACNA1C | |
| SCHEMBL2841656 | 0.80 | CYP2C9 (0.58) | CYP2C9CYP3A4CYP2C19KCNH2 | |
| SCHEMBL2835755 | 0.79 | CYP2C9 (0.42) | CYP2C9CYP3A4CYP2C19KCNH2CACNA1C | |
| SCHEMBL2840738 | 0.79 | CYP2C9 (0.42) | CYP2C9CYP3A4CYP2C19KCNH2CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265152-B2 | Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases | VIROPHARMA INCORPORATED (US) | 2007-09-04 | — | — | US | claimed |
| US-7265152-B2 | Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases | VIROPHARMA INCORPORATED (US) | 2007-09-04 | — | — | US | disclosed |