Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.40 |
| ▸ | CCND1 | P24385 | 13/20 | 0.40 |
| ▸ | CDK2 | P24941 | 13/20 | 0.40 |
| ▸ | CCND3 | P30281 | 13/20 | 0.40 |
| ▸ | MAP3K8 | P41279 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 6/20 | 0.38 |
| ▸ | JAK1 | P23458 | 6/20 | 0.38 |
| ▸ | TYK2 | P29597 | 6/20 | 0.38 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.37 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5520029 | 0.88 | MAP3K8 (0.49) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL14493382 | 0.81 | CDK2 (0.41) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5518736 | 0.80 | MAP3K8 (0.46) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL7501238 | 0.79 | CHEK1 (0.31) | CHEK1 | |
| SCHEMBL14493645 | 0.79 | MAP3K8 (0.46) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL14493453 | 0.79 | CHEK1 (0.31) | CHEK1 | |
| SCHEMBL5519384 | 0.78 | MAP3K8 (0.43) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5519377 | 0.78 | MAP3K8 (0.43) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5512136 | 0.78 | MAP3K8 (0.60) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5516821 | 0.77 | CDK1 (0.47) | CDK4CCNA2CCND1CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7232912-B2 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-7232912-B2 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-7232912-B2 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-20060111322-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. | 2006-05-25 | — | — | US | disclosed |
| US-20050239855-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. | 2005-10-27 | — | — | US | disclosed |
| US-6919461-B2 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | AGOURON PHARMACEUTICALS, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030139463-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | REICH SIEGFRIED HEINZ (US) | 2003-07-24 | — | — | US | disclosed |
| US-6555539-B2 | For treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, psoriasis | AGOURON PHARMACEUTICALS | 2003-04-29 | — | — | US | disclosed |
| EP-1250326-A2 | INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION | AGOURON PHARMACEUTICALS, INC. (US) | 2002-10-23 | — | — | EP | disclosed |
| WO-2001015656-A9 | TRICYCLIC COMPOUNDS AND THEIR USES AS ANTIARRHYTHMIC ANTIFIBRILLATORY AND DEFIBRILLATORY AGENTS | TECHNION RES & DEV FOUNDATION (IL) | 2002-04-18 | — | — | WO | disclosed |
| WO-2001053268-A2 | INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION | AGOURON PHARMACEUTICALS, INC. (US) | 2001-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239855-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | CDK3, MKI67, ROCK1 | CDK4 4/4885CCNA2 251/4885CCND1 178/4885 |
| US-20030139463-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | CDK3, MKI67, ROCK1 | CDK4 4/4885CCNA2 251/4885CCND1 178/4885 |
| US-20060111322-A1 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | MKI67, CCNI, CDK3 | CDK4 10/4885CCNA2 46/4885CCND1 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.