Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263446 | 0.85 | HTT (0.49) | HTTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL5260758 | 0.85 | HTT (0.49) | HTTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL5503903 | 0.82 | HTT (0.46) | HTTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL5252685 | 0.79 | HTT (0.47) | HTTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL22146133 | 0.76 | ATM (0.45) | HTTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL31294121 | 0.73 | DPP8 (0.56) | KMT2AMEN1 | |
| SCHEMBL5256409 | 0.73 | POLB (0.44) | HTTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL5256413 | 0.73 | POLB (0.44) | HTTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL5254334 | 0.72 | POLB (0.44) | HTTPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL5254332 | 0.72 | POLB (0.44) | HTTPOLBALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |