Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5519132 | 1.00 | PARP15 (0.45) | PARP15PARP10PARP2NR1H4CHRM4 | |
| SCHEMBL5519122 | 1.00 | PARP15 (0.45) | PARP15PARP10PARP2NR1H4CHRM4 | |
| SCHEMBL5521960 | 0.89 | CHRM4 (0.47) | CHRM4NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL5521965 | 0.89 | CHRM4 (0.47) | CHRM4NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL5518072 | 0.89 | NPC1 (0.47) | PARP15PARP10PARP2CNR2NPC1 | |
| SCHEMBL5519731 | 0.89 | PARP15 (0.46) | PARP15PARP10PARP2NR1H4CNR2 | |
| SCHEMBL5518075 | 0.89 | NPC1 (0.47) | PARP15PARP10PARP2CNR2NPC1 | |
| SCHEMBL5519740 | 0.89 | PARP15 (0.46) | PARP15PARP10PARP2NR1H4CNR2 | |
| SCHEMBL5519736 | 0.89 | PARP15 (0.46) | PARP15PARP10PARP2NR1H4CNR2 | |
| SCHEMBL5518070 | 0.89 | NPC1 (0.47) | PARP15PARP10PARP2CNR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167452-A1 | Therapeutic amide derivatives | PFIZER, INC. | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167452-A1 | Therapeutic amide derivatives | GRIN1, GRIN2B, GRIN3A | PARP15 3115/4885PARP10 3349/4885PARP2 4417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.